St. Louis, Missouri has 2 stand-up comedy clubs, including 2 venues that host open mic nights. Top venues include Helium Comedy Club, St. Louis Funny Bone. ComedyClubFinder lists every comedy club in St. Louis with addresses, ticket prices, show schedules, and venue details.
Discover 2 stand-up comedy clubs in St. Louis, Missouri. 2 venues host open mic nights. Find shows, tickets, and venue details for every comedy club in St. Louis.
Helium Comedy Club - St. Louis is a contemporary entertainment venue that bring stadium-sized talent to an intimate theater on a weekly basis.
Our club is local and family-owned with a close-knit staff, and we are proud to host both talent from the St Louis area and nationally touring comedians since 1984.
St. Louis, Missouri, boasts a dynamic stand-up comedy scene that mirrors the city's distinctive blend of Midwestern charm and spirited local culture. For those eager to catch national headliners, the Helium Comedy Club is a prime destination, offering a classic comedy club experience with a consistently lively atmosphere. Alternatively, the St. Louis Funny Bone provides another excellent venue for both established acts and emerging talent, often featuring a diverse lineup that caters to various comedic tastes. Weekends are typically reserved for touring professionals at both venues, guaranteeing a night of polished performances. However, if you're keen to witness the raw energy of developing comedians, the city's open mic nights, with two dedicated events, are a fantastic option, usually held on weeknights. Audiences in St. Louis are known for their enthusiastic and appreciative nature, often ready to engage with performers. To ensure you get the best seats, especially for popular shows, it is always advisable to book your tickets in advance.
St. Louis is the hometown of several notable comedians, including the legendary Cedric the Entertainer, known for his smooth delivery and charismatic stage presence.
For a convenient pre-show dinner or drinks, consider the Westport Plaza area, where the St. Louis Funny Bone is located, offering a variety of dining options within walking distance.
Verified venue data
All 2 venues verified against official websites and Google Business Profiles. We check for closures, address changes, and policy updates quarterly.
Real ratings from Google
Star ratings and review counts are sourced directly from Google Places — not estimated or fabricated. Only venues with a Google Business Profile listing are shown.
Last reviewed: April 2026
ComedyClubFinder reviews and updates venue data quarterly. Closed venues are removed; new venues are added as they open. If you spot an error, use the "Report an issue" link on each venue page.
No paid placements
Venue rankings and listings are based entirely on data quality, Google ratings, and completeness — not advertising spend. No club has paid to appear on ComedyClubFinder.
Stay in the loop
Unsubscribe anytime.