The top stand-up comedy venues in St. Louis, Missouri. Find shows, tickets, and venue details for the best comedy clubs in the city.
614 W Port Plaza Dr
Our club is local and family-owned with a close-knit staff, and we are proud to host both talent from the St Louis area and nationally touring comedians since 1984.
1151 St Louis Galleria
Helium Comedy Club - St. Louis is a contemporary entertainment venue that bring stadium-sized talent to an intimate theater on a weekly basis.
All St. Louis comedy clubs sell tickets online. Book in advance — popular shows sell out, especially on weekends.
Our club is local and family-owned with a close-knit staff, and we are proud to host both talent from the St Louis area and nationally touring comedians since 1984.
Helium Comedy Club - St. Louis is a contemporary entertainment venue that bring stadium-sized talent to an intimate theater on a weekly basis.
St. Louis"s top comedy clubs offer a diverse range of comedic experiences, attracting both seasoned headliners and rising stars. These venues are known for their intimate settings, allowing audiences to feel connected to the performers. You"ll find a mix of observational humor, storytelling, and high-energy acts, catering to a broad audience. The crowds here appreciate genuine talent and a good punchline, creating an engaging atmosphere where laughter is always the main event. It"s a place where both national acts and local favorites shine, making for memorable nights out.
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Last reviewed: April 2026
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