Top Picks

Best Comedy Clubs in St. Louis, MO

The top stand-up comedy venues in St. Louis, Missouri. Find shows, tickets, and venue details for the best comedy clubs in the city.

Top Picks in St. Louis

#1

St. Louis Funny Bone

614 W Port Plaza Dr

4.5(1,130 reviews)

Our club is local and family-owned with a close-knit staff, and we are proud to host both talent from the St Louis area and nationally touring comedians since 1984.

$28–$5521+Open Mic
#2

Helium Comedy Club

1151 St Louis Galleria

4.3(2,141 reviews)

Helium Comedy Club - St. Louis is a contemporary entertainment venue that bring stadium-sized talent to an intimate theater on a weekly basis.

$15–$3018+Open Mic

If You're Deciding What to Book Tonight

All St. Louis comedy clubs sell tickets online. Book in advance — popular shows sell out, especially on weekends.

All Comedy Clubs in St. Louis

#1

Our club is local and family-owned with a close-knit staff, and we are proud to host both talent from the St Louis area and nationally touring comedians since 1984.

(314) 469-669221+$28–$55
#2

Helium Comedy Club - St. Louis is a contemporary entertainment venue that bring stadium-sized talent to an intimate theater on a weekly basis.

(314) 727-126018+$15–$30

About St. Louis's Comedy Scene

St. Louis"s top comedy clubs offer a diverse range of comedic experiences, attracting both seasoned headliners and rising stars. These venues are known for their intimate settings, allowing audiences to feel connected to the performers. You"ll find a mix of observational humor, storytelling, and high-energy acts, catering to a broad audience. The crowds here appreciate genuine talent and a good punchline, creating an engaging atmosphere where laughter is always the main event. It"s a place where both national acts and local favorites shine, making for memorable nights out.

Why trust this guideto St. Louis, Missouri comedy clubs

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Last reviewed: April 2026

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