21+ Comedy Clubs in St. Louis, Missouri

Find 21-and-over comedy clubs in St. Louis, Missouri. Browse adult-only venues, show schedules, and ticket links.

• Helium Comedy Club — St. Louis, MO — rated 4.3/5 (2141 reviews) · tickets $15–$30 · open mic nights
• St. Louis Funny Bone — St. Louis, MO — rated 4.5/5 (1130 reviews) · tickets $28–$55 · open mic nights

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• All comedy clubs in St. Louis