21+ Comedy Clubs in Greenville, South Carolina

Find 21-and-over comedy clubs in Greenville, South Carolina. Browse adult-only venues, show schedules, and ticket links.

• The Comedy Zone — Greenville, SC — rated 4.5/5 (1372 reviews) · tickets $25–$55 · open mic nights
• Alchemy Comedy Theater — Greenville, SC — rated 4.5/5 (221 reviews) · tickets $10-$15 · open mic nights

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• All comedy clubs in Greenville